articleNature GeneticsMar 9, 2015HYBRID OA

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

SÖSuna Önengüt-GümüşcüWCWei‐Min ChenOSOliver S. BurrenNJNick J. CooperARAaron R. Quinlan

University of Virginia · University of Virginia Health System · +8 more institutions

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Abstract

Stephen Rich and colleagues report the discovery and fine mapping of type 1 diabetes susceptibility loci using the Immunochip. They also perform comparative analyses with 15 other immune disorders and find evidence of colocalization of causal variants with lymphoid gene enhancers. Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions1,2, finding major pathways contributing to risk3, with some loci shared across immune disorders4,5,6. To make genetic comparisons across autoimmune disorders as informative as possible, a dense genotyping array, the Immunochip, was developed, from which we identified four new T1D-associated regions (P

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Topics & keywords

Topics
Keywords
  • Biology
  • Genetics
  • Single-nucleotide polymorphism
  • Enhancer
  • Genome-wide association study
  • Genotyping
  • Genetic association
  • Concordance
UN Sustainable Development Goals
  • Good health and well-being
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