articleThe American Journal of Surgical PathologyMar 23, 2007Closed access

Inflammatory Myofibroblastic Tumor

CMCheryl M. CoffinJLJason L. HornickCDChristopher D.�M. Fletcher

University of Utah · Primary Children's Hospital · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate biologic potential. In this study, we report a subset of IMTs with histologic atypia and/or clinical aggressiveness that were analyzed for clinicopathologic features, outcome, and immunohistochemical expression of anaplastic lymphoma kinase (ALK) and other markers to identify potential pathologic prognostic features. Fifty-nine IMTs with classic morphology (5 cases), atypical histologic features (21 cases), local recurrence (27 cases), and/or metastasis (6 cases) were studied. Immunohistochemistry was performed for ALK1 and other markers (Mib-1, c-Myc, cyclin D1, caspase 3, Bcl-2, Mcl-1, survivin, p27, CD56, p53, MDM-2) using standard…

Citation impact

967
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20.45
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100%
References
74
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Authors

3

Topics & keywords

Topics
Keywords
  • Medicine
  • Pathology
  • Immunohistochemistry
  • Metastasis
  • Lung
  • Radiology
  • Cancer
  • Internal medicine
UN Sustainable Development Goals
  • Good health and well-being
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