Regulation of the Germinal Center Response by MicroRNA-155
Brigham and Women's Hospital · Harvard University · +4 more institutions
Abstract
MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.
Citation impact
- FWCI
- 48.76
- Percentile
- 100%
- References
- 25
Authors
15- TTTo‐Ha ThaiCorresponding
Brigham and Women's Hospital, Harvard University, Regeneron (United States), Max Delbrück Center, IFOM
- DPDinis Pedro Calado
Brigham and Women's Hospital, Boston Biomedical Research Institute, Harvard University, Regeneron (United States), Max Delbrück Center, IFOM
- SCStefano Casola
Brigham and Women's Hospital, Harvard University, Regeneron (United States), Max Delbrück Center, IFOM
- KMK. Mark Ansel
Brigham and Women's Hospital, Boston Biomedical Research Institute, Harvard University, Regeneron (United States), Max Delbrück Center, IFOM
- CXChangchun Xiao
Brigham and Women's Hospital, Boston Biomedical Research Institute, Harvard University, Regeneron (United States), Max Delbrück Center, IFOM
Topics & keywords
- microRNA
- Germinal center
- Biology
- Immune system
- Transgene
- Cell biology
- Cellular differentiation
- Genetics
- Life in Land