Oxidative stress and autophagy: the clash between damage and metabolic needs
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Abstract
Autophagy is a catabolic process aimed at recycling cellular components and damaged organelles in response to diverse conditions of stress, such as nutrient deprivation, viral infection and genotoxic stress. A growing amount of evidence in recent years argues for oxidative stress acting as the converging point of these stimuli, with reactive oxygen species (ROS) and reactive nitrogen species (RNS) being among the main intracellular signal transducers sustaining autophagy. This review aims at providing novel insight into the regulatory pathways of autophagy in response to glucose and amino acid deprivation, as well as their tight interconnection with metabolic networks and redox homeostasis. The role of…
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2,177
total citations
- FWCI
- 60.82
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- 100%
- References
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Authors
3Topics & keywords
Topics
Keywords
- Autophagy
- Cell biology
- Crosstalk
- Oxidative stress
- Reactive oxygen species
- Biology
- Autophagosome
- Reactive nitrogen species
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