reviewCurrent Medicinal ChemistryJan 1, 2005Closed access

Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design

LMLı́dia Moreira LimaEJEliezer J. Barreiro

Universidade Federal do Rio de Janeiro

PubMed
Indexed incrossrefpubmed

Abstract

This review aim to demonstrate the role of bioisosterism in rational drug design as well as in the molecular modification and optimization process aiming to improve pharmacodynamic and pharmacokinetic properties of lead compounds. Keywords: lead compound, isosterism, antagonist, pharmacodynamic, pharmacokinetic, hplc, prostaglandin-h synthase-2 (pghs-

Citation impact

656
total citations
FWCI
11.25
Percentile
100%
References
5
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Pharmacokinetics
  • Drug
  • Drug design
  • Pharmacodynamics
  • Chemistry
  • Pharmacology
  • Rational design
  • Lead compound
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