H 2 O 2 -Activatable and O 2 -Evolving Nanoparticles for Highly Efficient and Selective Photodynamic Therapy against Hypoxic Tumor Cells
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Abstract
The low selectivity of currently available photosensitizers, which causes the treatment-related toxicity and side effects on adjacent normal tissues, is a major limitation for clinical photodynamic therapy (PDT) against cancer. Moreover, since PDT process is strongly oxygen dependent, its therapeutic effect is seriously hindered in hypoxic tumor cells. To overcome these problems, a cell-specific, H(2)O(2)-activatable, and O(2)-evolving PDT nanoparticle (HAOP NP) is developed for highly selective and efficient cancer treatment. The nanoparticle is composed of photosensitizer and catalase in the aqueous core, black hole quencher in the polymeric shell, and functionalized with a tumor targeting ligand c(RGDfK).…
Citation impact
804
total citations
- FWCI
- 39.67
- Percentile
- 100%
- References
- 36
Citations per year
Authors
4Topics & keywords
Topics
Keywords
- Photodynamic therapy
- Photosensitizer
- Chemistry
- Singlet oxygen
- Cancer cell
- Tumor hypoxia
- Biophysics
- Catalase
UN Sustainable Development Goals
- Good health and well-being
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