Autophagy promotes MHC class II presentation of peptides from intracellular source proteins
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Abstract
MHC-peptide complexes mediate key functions in adaptive immunity. In a classical view, MHC-I molecules present peptides from intracellular source proteins, whereas MHC-II molecules present antigenic peptides from exogenous and membrane proteins. Nevertheless, substantial crosstalk between these two pathways has been observed. We investigated the influence of autophagy on the MHC-II ligandome and demonstrated that peptide presentation is altered considerably upon induction of autophagy. The presentation of peptides from intracellular and lysosomal source proteins was strongly increased on MHC-II in contrast with peptides from membrane and secreted proteins. In addition, autophagy influenced the MHC-II…
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632
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Authors
14Topics & keywords
Topics
Keywords
- Antigen processing
- Antigen presentation
- Autophagy
- MHC class I
- Cell biology
- Major histocompatibility complex
- Intracellular
- MHC class II
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