A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants
University of North Carolina at Chapel Hill · Johns Hopkins University · +6 more institutions
Abstract
Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 Finnish normal glucose-tolerant (NGT) controls with >315,000 single-nucleotide polymorphisms (SNPs) and imputed genotypes for an additional >2 million autosomal SNPs. We carried out association analysis with these SNPs to identify genetic variants that predispose to T2D, compared our T2D association results with the results of two similar studies, and genotyped 80 SNPs in an additional 1215 Finnish T2D cases and 1258 Finnish NGT controls. We identify T2D-associated variants in an intergenic region of…
Citation impact
- FWCI
- 201.63
- Percentile
- 100%
- References
- 31
Authors
41- LJLaura J. Scott
University of North Carolina at Chapel Hill, Johns Hopkins University, Calvin University, University of Michigan, Johns Hopkins Medicine, National Human Genome Research Institute
- KLKaren L. Mohlke
University of North Carolina at Chapel Hill, Johns Hopkins University, Calvin University, University of Michigan, Johns Hopkins Medicine, National Human Genome Research Institute
- LLLori L. Bonnycastle
University of North Carolina at Chapel Hill, Johns Hopkins University, Calvin University, University of Michigan, Johns Hopkins Medicine, National Human Genome Research Institute
- CJCristen J. Willer
University of North Carolina at Chapel Hill, Johns Hopkins University, Calvin University, University of Michigan, Johns Hopkins Medicine, National Human Genome Research Institute
- YLYun Li
University of North Carolina at Chapel Hill, Johns Hopkins University, Calvin University, University of Michigan, Johns Hopkins Medicine, National Human Genome Research Institute
Topics & keywords
- Single-nucleotide polymorphism
- TCF7L2
- Genetics
- Biology
- Type 2 diabetes
- Genome-wide association study
- Genetic association
- FTO gene
- Good health and well-being