Flexible Porous Metal-Organic Frameworks for a Controlled Drug Delivery
Université de Montpellier · Centre National de la Recherche Scientifique · +3 more institutions
Abstract
Flexible nanoporous chromium or iron terephtalates (BDC) MIL-53(Cr, Fe) or M(OH)[BDC] have been used as matrices for the adsorption and in vitro drug delivery of Ibuprofen (or alpha- p-isobutylphenylpropionic acid). Both MIL-53(Cr) and MIL-53(Fe) solids adsorb around 20 wt % of Ibuprofen (Ibuprofen/dehydrated MIL-53 molar ratio = 0.22(1)), indicating that the amount of inserted drug does not depend on the metal (Cr, Fe) constitutive of the hybrid framework. Structural and spectroscopic characterizations are provided for the solid filled with Ibuprofen. In each case, the very slow and complete delivery of Ibuprofen was achieved under physiological conditions after 3 weeks with a predictable zero-order kinetics,…
Citation impact
- FWCI
- 40.56
- Percentile
- 100%
- References
- 29
Authors
9- PHPatricia HorcajadaCorresponding
Université de Montpellier, Centre National de la Recherche Scientifique, Institut Charles Gerhardt Montpellier, Institut Universitaire de France, Universidad Complutense de Madrid
- CSChristian Serre
Institut Charles Gerhardt Montpellier, Institut Universitaire de France, Centre National de la Recherche Scientifique, Université de Montpellier, Universidad Complutense de Madrid
- GMGuillaume Maurin
Centre National de la Recherche Scientifique, Universidad Complutense de Madrid, Institut Charles Gerhardt Montpellier, Institut Universitaire de France, Université de Montpellier
- NANaseem A. Ramsahye
Institut Charles Gerhardt Montpellier, Université de Montpellier, Universidad Complutense de Madrid, Centre National de la Recherche Scientifique, Institut Universitaire de France
- FBFrancisco Balas
Universidad Complutense de Madrid, Institut Universitaire de France, Université de Montpellier, Institut Charles Gerhardt Montpellier, Centre National de la Recherche Scientifique
Topics & keywords
- Ibuprofen
- Chemistry
- Nanoporous
- Metal-organic framework
- Drug delivery
- Porosity
- Adsorption
- Chemical engineering