articleProceedings of the National Academy of SciencesFeb 9, 2008GREEN OA

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

JEJane E. LaucknerJBJill B. JensenHCHuei-Ying ChenHLHui‐Chen LuBHBertil Hille

University of Washington · Baylor College of Medicine · +1 more institution

PubMed
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Abstract

The CB(1) cannabinoid receptor mediates many of the psychoactive effects of Delta(9)THC, the principal active component of cannabis. However, ample evidence suggests that additional non-CB(1)/CB(2) receptors may contribute to the behavioral, vascular, and immunological actions of Delta(9)THC and endogenous cannabinoids. Here, we provide further evidence that GPR55, a G protein-coupled receptor, is a cannabinoid receptor. GPR55 is highly expressed in large dorsal root ganglion neurons and, upon activation by various cannabinoids (Delta(9)THC, the anandamide analog methanandamide, and JWH015) increases intracellular calcium in these neurons. Examination of its signaling pathway in HEK293 cells transiently…

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701
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Topics & keywords

Topics
Keywords
  • Cannabinoid receptor
  • Cannabinoid
  • GPR18
  • Anandamide
  • Cannabinoid Receptor Agonists
  • Cannabinoid receptor type 2
  • Calcium in biology
  • Chemistry
UN Sustainable Development Goals
  • Good health and well-being
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