Metabolic Crisis without Brain Ischemia is Common after Traumatic Brain Injury: A Combined Microdialysis and Positron Emission Tomography Study
University of California, Los Angeles · Olive View-UCLA Medical Center
Abstract
Brain trauma is accompanied by regional alterations of brain metabolism, reduction in metabolic rates and possible energy crisis. We hypothesize that microdialysis markers of energy crisis are present during the critical period of intensive care despite the absence of brain ischemia. In all, 19 brain injury patients (mean GCS 6) underwent combined positron emission tomography (PET) for metabolism of glucose (CMRglu) and oxygen (CMRO(2)) and cerebral microdialysis (MD) at a mean time of 36 h after injury. Microdialysis values were compared with the regional mean PET values adjacent to the probe. Longitudinal MD data revealed a 25% incidence rate of metabolic crisis (elevated lactate/pyruvate ratio (LPR) > 40)…
Citation impact
- FWCI
- 17.51
- Percentile
- 100%
- References
- 48
Authors
9- PVPaul VespaCorresponding
University of California, Los Angeles, Olive View-UCLA Medical Center
- MBMarvin Bergsneider
University of California, Los Angeles, Olive View-UCLA Medical Center
- NHNayoa Hattori
University of California, Los Angeles, Olive View-UCLA Medical Center
- HWHsiao-Ming Wu
University of California, Los Angeles, Olive View-UCLA Medical Center
- SHSung‐Cheng Huang
University of California, Los Angeles, Olive View-UCLA Medical Center
Topics & keywords
- Microdialysis
- Positron emission tomography
- Ischemia
- Medicine
- Traumatic brain injury
- Anesthesia
- Brain ischemia
- Internal medicine
- Affordable and clean energy