Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
University of Bologna · University of Turku · +3 more institutions
Abstract
BACKGROUND: Age-related physiological changes in the gastrointestinal tract, as well as modifications in lifestyle, nutritional behaviour, and functionality of the host immune system, inevitably affect the gut microbiota, resulting in a greater susceptibility to infections. METHODOLOGY/PRINCIPAL FINDINGS: By using the Human Intestinal Tract Chip (HITChip) and quantitative PCR of 16S rRNA genes of Bacteria and Archaea, we explored the age-related differences in the gut microbiota composition among young adults, elderly, and centenarians, i.e subjects who reached the extreme limits of the human lifespan, living for over 100 years. We observed that the microbial composition and diversity of the gut ecosystem of…
Citation impact
- FWCI
- 22.87
- Percentile
- 100%
- References
- 74
Authors
12Topics & keywords
- Biology
- Gut flora
- Firmicutes
- Ageing
- Human microbiome
- Population
- Eubacterium
- Microbiome
- Zero hunger