Activation of p53 by MEG3 Non-coding RNA
Harvard University · Massachusetts General Hospital
Abstract
MEG3 is a maternally expressed imprinted gene suggested to function as a non-coding RNA. Our previous studies suggest that MEG3 has a function of tumor suppression. The tumor suppressor p53 plays a central role in tumor suppression and mediates the functions of many other tumor suppressors. Therefore, we hypothesized that MEG3 functions through activation of p53. We found that transfection of expression constructs for MEG3 and its isoforms results in a significant increase in p53 protein levels and dramatically stimulates p53-dependent transcription from a p53-responsive promoter. Using this as the functional assay, we demonstrated that the open reading frames encoded by MEG3 transcripts are not required for…
Citation impact
- FWCI
- 3.90
- Percentile
- 100%
- References
- 58
Authors
10- YZYunli ZhouCorresponding
Harvard University, Massachusetts General Hospital
- YZYing Zhong
Harvard University, Massachusetts General Hospital
- YWYingying Wang
Harvard University, Massachusetts General Hospital
- XZXun Zhang
Harvard University, Massachusetts General Hospital
- DLDalia L. Batista
Harvard University, Massachusetts General Hospital
Topics & keywords
- MEG3
- Biology
- RNA
- Long non-coding RNA
- Transcription (linguistics)
- Gene expression
- Mdm2
- Cancer research