The human disease network
University of Notre Dame · Harvard University · +5 more institutions
Abstract
A network of disorders and disease genes linked by known disorder-gene associations offers a platform to explore in a single graph-theoretic framework all known phenotype and disease gene associations, indicating the common genetic origin of many diseases. Genes associated with similar disorders show both higher likelihood of physical interactions between their products and higher expression profiling similarity for their transcripts, supporting the existence of distinct disease-specific functional modules. We find that essential human genes are likely to encode hub proteins and are expressed widely in most tissues. This suggests that disease genes also would play a central role in the human interactome. In…
Citation impact
- FWCI
- 56.24
- Percentile
- 100%
- References
- 33
Authors
6- KGK.-I. GohCorresponding
University of Notre Dame, Harvard University, Korea University, Center for Systems Biology
- MEMichael E. Cusick
Harvard University, Dana-Farber Cancer Institute, Center for Systems Biology
- DVDavid Valle
Johns Hopkins University, Johns Hopkins Medicine
- BCBarton Childs
Johns Hopkins University, Johns Hopkins Medicine
- MVMarc Vidal
Harvard University, Dana-Farber Cancer Institute, Center for Systems Biology
Topics & keywords
- ENCODE
- Biology
- Gene
- Interactome
- Phenotype
- Disease
- Genetics
- Computational biology