Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
Oregon State University · Baylor College of Medicine · +1 more institution
Abstract
Glutathione (GSH) significantly declines in the aging rat liver. Because GSH levels are partly a reflection of its synthetic capacity, we measured the levels and activity of gamma-glutamylcysteine ligase (GCL), the rate-controlling enzyme in GSH synthesis. With age, both the catalytic (GCLC) and modulatory (GCLM) subunits of GCL decreased by 47% and 52%, respectively (P
Citation impact
- FWCI
- 8.20
- Percentile
- 100%
- References
- 46
Authors
7- JHJung H. Suh
Oregon State University, Baylor College of Medicine, University of Alabama at Birmingham
- SVSwapna V. Shenvi
Oregon State University, Baylor College of Medicine, University of Alabama at Birmingham
- BDBrian Dixon
Oregon State University, Baylor College of Medicine, University of Alabama at Birmingham
- HLHonglei Liu
Oregon State University, Baylor College of Medicine, University of Alabama at Birmingham
- AKAnil K. Jaiswal
Oregon State University, Baylor College of Medicine, University of Alabama at Birmingham
Topics & keywords
- GCLC
- GCLM
- Glutathione
- Lipoic acid
- Internal medicine
- Oxidative stress
- Endocrinology
- In vivo