HECT and RING finger families of E3 ubiquitin ligases at a glance

The post-translational attachment of ubiquitin, a highly conserved 76-amino-acid polypeptide, directs myriad eukaryotic proteins to a variety of fates and functions. Ubiquitylation is best-known for targeting proteins for degradation by the 26S proteasome. Other functions include internalization and lysosomal targeting, modulation of protein interactions, alteration of subcellular distribution, regulation of transcription, DNA repair and propagation of transmembrane signaling, most notably in the NF-κB pathway. Not surprisingly, ubiquitylation has been linked to virtually every cellular process.Ubiquitylation occurs through the sequential action of three classes of protein: ubiquitin-activating enzymes (E1s),…

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  Division of Chemistry