HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway
Technical University of Munich · Institute of Medical Microbiology and Hygiene · +2 more institutions
Abstract
Human heat-shock protein (HSP)70 activates innate immune cells and hence requires no additional adjuvants to render bound peptides immunogenic. Here we tested the assumption that endogenous HSP70 activates the Toll/IL-1 receptor signal pathway similar to HSP60 and pathogen-derived molecular patterns. We show that HSP70 induces interleukin-12 (IL-12) and endothelial cell-leukocyte adhesion molecule-1 (ELAM-1) promoters in macrophages and that this is controlled by MyD88 and TRAF6. Furthermore, HSP70 causes MyD88 relocalization and MyD88-deficient dendritic cells do not respond to HSP70 with proinflammatory cytokine production. Using the system of genetic complementation with Toll-like receptors (TLR) we found…
Citation impact
- FWCI
- 22.34
- Percentile
- 100%
- References
- 30
Authors
6- RMR. Martin VabulasCorresponding
Technical University of Munich, Institute of Medical Microbiology and Hygiene
- PAParviz Ahmad‐Nejad
Institute of Medical Microbiology and Hygiene, Technical University of Munich
- SGSanghamitra Ghose
Ludwig-Maximilians-Universität München
- CJCarsten J. Kirschning
Institute of Medical Microbiology and Hygiene, Technical University of Munich
- RDRolf D. Issels
Institute of Bioinformatics and Systems Biology, Ludwig-Maximilians-Universität München
Topics & keywords
- Endogeny
- Stimulus (psychology)
- Receptor
- Neuroscience
- Chemistry
- Biology
- Psychology
- Endocrinology