reviewEuropean Journal of ImmunologyOct 31, 2007BRONZE OA

Historical insights into cytokines

CAC A Dinarello

University of Colorado Health · University of Colorado Anschutz Medical Campus

PubMed
Indexed incrossrefpubmed

Abstract

Cytokines affect nearly every biological process; these include embryonic development, disease pathogenesis, non-specific response to infection, specific response to antigen, changes in cognitive functions and progression of the degenerative processes of aging. In addition, cytokines are part of stem cell differentiation, vaccine efficacy and allograft rejection. This short insight focuses on the milestones in cytokine biology and how the various and often contradictory activities of these small, non-structural proteins affected the fields of inflammation and immunology. Multiple biological properties or pleiotropism is the hallmark of a cytokine. Today, the term "cytokine" encompasses interferons, the…

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916
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100%
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Authors

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Topics & keywords

Topics
Keywords
  • Cytokine
  • Biology
  • Immunology
  • Chemokine
  • Tumor necrosis factor alpha
  • Disease
  • Inflammation
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
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