Immune evasion in cancer: Mechanistic basis and therapeutic strategies

Cancer immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Although considerable progress has been made in understanding how cancers evade destructive immunity, measures to counteract tumor escape have not kept pace. There are a number of factors that contribute to tumor persistence despite having a normal host immune system. Immune editing is one of the key aspects why tumors evade surveillance causing the tumors to lie dormant in patients for years through "equilibrium" and "senescence" before re-emerging. In addition, tumors exploit several immunological processes such as targeting the regulatory T cell function or their secretions, antigen presentation,…

• CF
  Center for Hierarchical Manufacturing, National Science Foundation
• CR
  Cancer Research UK

  Award: C301/A14762
• NR
  National Research Foundation

  Award: NRF-2005-0093837
• NC
  National Cancer Institute

  Award: NCC-1310430-2