Potential risks of bone marrow cell transplantation into infarcted hearts

Breitbach, Martin; Bostani, Toktam; Roell, Wilhelm; Xia, Ying; Dewald, Oliver; Nygren, Jens; Fries, Jochen W.U.; Tiemann, Klaus; Bohlen, Heribert; Hescheler, Juergen; Welz, Armin; Bloch, Wilhelm; Jacobsen, Sten Eirik W.; Fleischmann, Bernd K.

doi:10.1182/blood-2006-12-063412

articleBloodMay 4, 2007BRONZE OA

Potential risks of bone marrow cell transplantation into infarcted hearts

MBMartin Breitbach TBToktam Bostani WRWilhelm Roell YXYing Xia ODOliver Dewald

University of Bonn · Czech Academy of Sciences, Institute of Physiology · +3 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Cellular replacement therapy has emerged as a novel strategy for the treatment of heart failure. The aim of our study was to determine the fate of injected mesenchymal stem cells (MSCs) and whole bone marrow (BM) cells in the infarcted heart. MSCs were purified from BM of transgenic mice and characterized using flow cytometry and in vitro differentiation assays. Myocardial infarctions were generated in mice and different cell populations including transgenic MSCs, unfractionated BM cells, or purified hematopoietic progenitors were injected. Encapsulated structures were found in the infarcted areas of a large fraction of hearts after injecting MSCs (22 of 43, 51.2%) and unfractionated BM cells (6 of 46, 13.0%).…

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Topics & keywords

Topics

Keywords

Mesenchymal stem cell
Bone marrow
Haematopoiesis
Progenitor cell
Transplantation
Stem cell
Medicine
Myocardial infarction

UN Sustainable Development Goals

Good health and well-being

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