articleCirculationJun 1, 2005Closed access

Reduced Number of Circulating Endothelial Progenitor Cells Predicts Future Cardiovascular Events

CSCaroline Schmidt‐LuckeLRLothar RössigSFStephan FichtlschererMVMariuca VasaMBMartina Britten

Goethe University Frankfurt

PubMed
Indexed incrossrefpubmed

Abstract

BACKGROUND: The maintenance of endothelial integrity plays a critical role in preventing atherosclerotic disease progression. Endothelial progenitor cells (EPCs) were experimentally shown to incorporate into sites of neovascularization and home to sites of endothelial denudation. Circulating EPCs may thus provide an endogenous repair mechanism to counteract ongoing risk factor-induced endothelial injury and to replace dysfunctional endothelium. METHODS AND RESULTS: In 120 individuals (43 control subjects, 44 patients with stable coronary artery disease, and 33 patients with acute coronary syndromes), circulating EPCs were defined by the surface markers CD34+KDR+ and analyzed by flow cytometry. Cardiovascular…

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Topics & keywords

Topics
Keywords
  • Medicine
  • Progenitor cell
  • Endothelial progenitor cell
  • Cardiology
  • Endothelial stem cell
  • Internal medicine
  • Stem cell
  • Cell biology
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