A Chelator-Free Multifunctional [ 64 Cu]CuS Nanoparticle Platform for Simultaneous Micro-PET/CT Imaging and Photothermal Ablation Therapy
Texas Southern University · The University of Texas MD Anderson Cancer Center · +1 more institution
Abstract
We synthesized and evaluated a novel class of chelator-free [(64)Cu]CuS nanoparticles (NPs) suitable both for PET imaging and as photothermal coupling agents for photothermal ablation. These [(64)Cu]CuS NPs are simple to make, possess excellent stability, and allow robust noninvasive micro-PET imaging. Furthermore, the CuS NPs display strong absorption in the near-infrared (NIR) region (peak at 930 nm); passive targeting prefers the tumor site, and mediated ablation of U87 tumor cells occurs upon exposure to NIR light both in vitro and in vivo after either intratumoral or intravenous injection. The combination of small diameter (∼11 nm), strong NIR absorption, and integration of (64)Cu as a structural…
Citation impact
- FWCI
- 16.10
- Percentile
- 100%
- References
- 40
Authors
9- MZMin ZhouCorresponding
Texas Southern University, The University of Texas MD Anderson Cancer Center
- RZRui Zhang
The University of Texas MD Anderson Cancer Center, Texas Southern University
- MHMiao Huang
Texas Southern University, The University of Texas MD Anderson Cancer Center
- WLWei Lü
The University of Texas MD Anderson Cancer Center, Texas Southern University
- SSShaoli Song
Shanghai Jiao Tong University, Texas Southern University, The University of Texas MD Anderson Cancer Center
Topics & keywords
- Photothermal therapy
- Chemistry
- Nanoparticle
- Ablation
- In vivo
- Absorption (acoustics)
- Pet imaging
- Molecular imaging