Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy

Mesenchymal stem cells (MSCs) are adult multipotent cells that give rise to various cell types of the mesodermal germ layer. MSCs are of great interest in the field of regenerative medicine and cancer therapy because of their unique ability to home to damaged and cancerous tissue. These cells also regulate the immune response and contribute to reparative processes in different pathological conditions, including musculoskeletal and cardiovascular diseases. The use of MSCs for tissue repair was initially based on the hypothesis that these cells home to and differentiate within the injured tissue into specialized cells. However, it now appears that only a small proportion of transplanted MSCs actually integrate…

• NO
  Nederlandse Organisatie voor Wetenschappelijk Onderzoek
• FI
  Fondazione Italiana per la Ricerca sul Cancro