An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
University of Aberdeen · University of Ferrara · +2 more institutions
Abstract
The vanilloid receptor VR1 is a nonselective cation channel that is most abundant in peripheral sensory fibers but also is found in several brain nuclei. VR1 is gated by protons, heat, and the pungent ingredient of "hot" chili peppers, capsaicin. To date, no endogenous compound with potency at this receptor comparable to that of capsaicin has been identified. Here we examined the hypothesis, based on previous structure-activity relationship studies and the availability of biosynthetic precursors, that N-arachidonoyl-dopamine (NADA) is an endogenous "capsaicin-like" substance in mammalian nervous tissues. We found that NADA occurs in nervous tissues, with the highest concentrations being found in the striatum,…
Citation impact
- FWCI
- 22.53
- Percentile
- 100%
- References
- 35
Authors
15- SMSusan M. Huang
University of Aberdeen, University of Ferrara, National Research Council
- TBTiziana Bisogno
University of Aberdeen, University of Ferrara, National Research Council
- MTMarcello Trevisani
University of Aberdeen, University of Ferrara, National Research Council
- AAAbdulmonem Al‐Hayani
University of Aberdeen, University of Ferrara, National Research Council
- LDLuciano De Petrocellis
University of Aberdeen, University of Ferrara, National Research Council
Topics & keywords
- Capsaicin
- Substance P
- Dorsal root ganglion
- Chemistry
- Calcitonin gene-related peptide
- TRPV1
- Receptor
- Resiniferatoxin