Acetylcholinesterase Inhibitors: Pharmacology and Toxicology
University of Belgrade · Bentham Science Publishers (China) · +1 more institution
Abstract
Acetylcholinesterase is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. The enzyme inactivation, induced by various inhibitors, leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins. This review presents an overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds. In the case of reversible inhibitors being…
Citation impact
- FWCI
- 56.15
- Percentile
- 100%
- References
- 180
Authors
5Topics & keywords
- Acetylcholinesterase
- Galantamine
- Pharmacology
- Rivastigmine
- Acetylcholine
- Cholinesterase
- Nerve agent
- Chemistry
- Good health and well-being