STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells
The University of Texas MD Anderson Cancer Center · Versiti Blood Center of Wisconsin
Abstract
Interleukin-17 (IL-17)-producing helper T (TH) cells, named as TH(IL-17), TH17, or inflammatory TH (THi), have been recently identified as a novel effector lineage. However, how cytokine signals mediate THi differentiation is unclear. We found that IL-6 functioned to up-regulate IL-23R and that IL-23 synergized with IL-6 in promoting THi generation. STAT3, activated by both IL-6 and IL-23, plays a critical role in THi development. A hyperactive form of STAT3 promoted THi development, whereas this differentiation process was greatly impaired in STAT3-deficient T cells. Moreover, STAT3 regulated the expression of retinoic acid receptor-related orphan receptor gamma-T (RORgamma t), a THi-specific transcriptional…
Citation impact
- FWCI
- 30.84
- Percentile
- 100%
- References
- 32
Authors
7- XOXuexian O. YangCorresponding
The University of Texas MD Anderson Cancer Center
- ADAthanasia D. Panopoulos
The University of Texas MD Anderson Cancer Center
- RNRoza Nurieva
The University of Texas MD Anderson Cancer Center
- SHSeon Hee Chang
The University of Texas MD Anderson Cancer Center
- DWDemin Wang
Versiti Blood Center of Wisconsin
Topics & keywords
- Cytokine
- Cell biology
- Immunology
- Biology
- Chemistry