Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
California Institute of Technology · University of California, Los Angeles · +1 more institution
Abstract
Targeted delivery represents a promising approach for the development of safer and more effective therapeutics for oncology applications. Although macromolecules accumulate nonspecifically in tumors through the enhanced permeability and retention (EPR) effect, previous studies using nanoparticles to deliver chemotherapeutics or siRNA demonstrated that attachment of cell-specific targeting ligands to the surface of nanoparticles leads to enhanced potency relative to nontargeted formulations. Here, we use positron emission tomography (PET) and bioluminescent imaging to quantify the in vivo biodistribution and function of nanoparticles formed with cyclodextrin-containing polycations and siRNA. Conjugation of…
Citation impact
- FWCI
- 19.24
- Percentile
- 100%
- References
- 30
Authors
5- DWDerek W. Bartlett
California Institute of Technology
- HCHelen C. Su
University of California, Los Angeles
- IJIsabel J. Hildebrandt
University of California, Los Angeles
- WWWolfgang Weber
University of Freiburg, University of California, Los Angeles
- MEMark E. DavisCorresponding
California Institute of Technology
Topics & keywords
- Biodistribution
- In vivo
- Preclinical imaging
- Chemistry
- Biophysics
- Positron emission tomography
- Molecular imaging
- Nanoparticle