Protein carbonylation, cellular dysfunction, and disease progression
University of Milan · University of Siena
Abstract
Carbonylation of proteins is an irreversible oxidative damage, often leading to a loss of protein function, which is considered a widespread indicator of severe oxidative damage and disease-derived protein dysfunction. Whereas moderately carbonylated proteins are degraded by the proteasomal system, heavily carbonylated proteins tend to form high-molecular-weight aggregates that are resistant to degradation and accumulate as damaged or unfolded proteins. Such aggregates of carbonylated proteins can inhibit proteasome activity. Alarge number of neurodegenerative diseases are directly associated with the accumulation of proteolysis-resistant aggregates of carbonylated proteins in tissues. Identification of…
Citation impact
- FWCI
- 20.12
- Percentile
- 100%
- References
- 142
Authors
6Topics & keywords
- Protein Carbonylation
- Proteolysis
- Proteasome
- Oxidative phosphorylation
- Oxidative stress
- Protein aggregation
- Protein degradation
- Carbonylation