Principles of interleukin (IL)-6-type cytokine signalling and its regulation
Indexed incrossrefpubmed
Abstract
The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are an important family of mediators involved in the regulation of the acute-phase response to injury and infection. Besides their functions in inflammation and the immune response, these cytokines play also a crucial role in haematopoiesis, liver and neuronal regeneration, embryonal development and fertility. Dysregulation of IL-6-type cytokine signalling contributes to the onset and maintenance of several diseases, such as rheumatoid arthritis, inflammatory bowel disease, osteoporosis, multiple sclerosis and various types of…
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3,235
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Authors
6Topics & keywords
Topics
Keywords
- Suppressor of cytokine signaling 1
- Oncostatin M
- Janus kinase
- Leukemia inhibitory factor
- Janus kinase 1
- JAK-STAT signaling pathway
- Cancer research
- Suppressor of cytokine signalling
UN Sustainable Development Goals
- Good health and well-being
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