Nanostructured Hydrogels for Three‐Dimensional Cell Culture Through Self‐Assembly of Fluorenylmethoxycarbonyl–Dipeptides

Jayawarna, Vineetha; Ali, Mohd Sajid; Jowitt, Thomas A.; Miller, Aline F.; Saiani, Alberto; Gough, Julie E.; Ulijn, Rein V.

doi:10.1002/adma.200501522

articleAdvanced MaterialsMar 2, 2006Closed access

Nanostructured Hydrogels for Three‐Dimensional Cell Culture Through Self‐Assembly of Fluorenylmethoxycarbonyl–Dipeptides

VJVineetha Jayawarna MSMohd Sajid Ali TAThomas A. Jowitt AFAline F. Miller ASAlberto Saiani

International Union of Pure and Applied Chemistry · University of Manchester · +1 more institution

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Abstract

A number of short peptide amphiphiles consisting of dipeptides linked to fluorenylmethoxycarbonyl spontaneously form fibrous hydrogels under physiological conditions (see figure). The structural and physical properties of these gels are dictated by the amino acid sequence of the peptide building blocks, and the gels support the three-dimensional cell culture of chondrocytes.

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Topics

Keywords

Self-healing hydrogels
Peptide
Materials science
Amphiphile
Self-assembly
Self-assembling peptide
Dipeptide
Tissue engineering

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