Recycling Endosomes Supply AMPA Receptors for LTP
Duke University · Brown University · +2 more institutions
Abstract
Long-term potentiation (LTP) of synaptic strength, the most established cellular model of information storage in the brain, is expressed by an increase in the number of postsynaptic AMPA receptors. However, the source of AMPA receptors mobilized during LTP is unknown. We report that AMPA receptors are transported from recycling endosomes to the plasma membrane for LTP. Stimuli that triggered LTP promoted not only AMPA receptor insertion but also generalized recycling of cargo and membrane from endocytic compartments. Thus, recycling endosomes supply AMPA receptors for LTP and provide a mechanistic link between synaptic potentiation and membrane remodeling during synapse modification.
Citation impact
- FWCI
- 12.10
- Percentile
- 100%
- References
- 30
Authors
5- MPMikyoung ParkCorresponding
Duke University, Brown University, Duke Medical Center, Duke University Hospital
- ECEsther C. PenickCorresponding
Duke University, Brown University, Duke Medical Center, Duke University Hospital
- JGJeffrey G. Edwards
Duke University, Brown University, Duke Medical Center, Duke University Hospital
- JAJulie A. Kauer
Duke University, Brown University, Duke Medical Center, Duke University Hospital
- MEMichael EhlersCorresponding
Duke University, Brown University, Duke Medical Center, Duke University Hospital
Topics & keywords
- AMPA receptor
- Long-term potentiation
- Silent synapse
- Endosome
- Endocytic cycle
- Long-term depression
- Postsynaptic potential
- Synapse