Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABA A receptors
Centre National de la Recherche Scientifique · University of California, Los Angeles · +1 more institution
Abstract
Neuroactive steroids are potent modulators of gamma-aminobutyric acid type A receptors (GABAARs), and their behavioral effects are generally viewed in terms of altered inhibitory synaptic transmission. Here we report that, at concentrations known to occur in vivo, neuroactive steroids specifically enhance a tonic inhibitory conductance in central neurons that is mediated by extrasynaptic delta subunit-containing GABAARs. The neurosteroid-induced augmentation of this tonic conductance decreases neuronal excitability. Fluctuations in the circulating concentrations of endogenous neuroactive steroids have been implicated in the genesis of premenstrual syndrome, postpartum depression, and other anxiety disorders.…
Citation impact
- FWCI
- 12.71
- Percentile
- 100%
- References
- 66
Authors
5- BMBrandon M. StellCorresponding
Centre National de la Recherche Scientifique, University of California, Los Angeles, University College London
- SGStephen G. Brickley
University of California, Los Angeles, University College London
- CTChih‐Yung Tang
University of California, Los Angeles, University College London
- MFMark Farrant
University of California, Los Angeles, University College London
- IMIstván Módy
Topics & keywords
- Neuroactive steroid
- GABAA receptor
- Inhibitory postsynaptic potential
- Tonic (physiology)
- Allopregnanolone
- Chemistry
- Pregnanolone
- Neuroscience
- Good health and well-being