Caspases: pharmacological manipulation of cell death
Heidelberg University · German Cancer Research Center
Indexed incrossrefdoajpubmed
Abstract
Caspases, a family of cysteine proteases, play a central role in apoptosis. During the last decade, major progress has been made to further understand caspase structure and function, providing a unique basis for drug design. This Review gives an overview of caspases and their classification, structure, and substrate specificity. We also describe the current knowledge of how interference with caspase signaling can be used to pharmacologically manipulate cell death.
Citation impact
639
total citations
- FWCI
- 15.32
- Percentile
- 100%
- References
- 102
Citations per year
Authors
1Topics & keywords
Topics
Keywords
- Caspase
- Proteases
- Apoptosis
- Programmed cell death
- Cell biology
- Intrinsic apoptosis
- Caspase 2
- Function (biology)
UN Sustainable Development Goals
- Good health and well-being
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