Natural product and natural product derived drugs in clinical trials
The University of Queensland · Division of Chemistry · +1 more institution
Abstract
There are a significant number of natural product (NP) drugs in development. We review the 100 NP and NP-derived compounds and 33 Antibody Drug Conjugates (ADCs) with a NP-derived cytotoxic component being evaluated in clinical trials or in registration at the end of 2013. 38 of these compounds and 33 ADCs are being investigated as potential oncology treatments, 26 as anti-infectives, 19 for the treatment of cardiovascular and metabolic diseases, 11 for inflammatory and related diseases and 6 for neurology. There was a spread of the NP and NP-derived compounds through the different development phases (17 in phase I, 52 in phase II, 23 in phase III and 8 NDA and/or MAA filed), while there were 23 ADCs in phase…
Citation impact
- FWCI
- 23.76
- Percentile
- 100%
- References
- 532
Authors
3- MSMark S. ButlerCorresponding
The University of Queensland, Division of Chemistry, Research Institute for Bioscience and Biotechnology
- AAAvril A. B. Robertson
The University of Queensland, Division of Chemistry, Research Institute for Bioscience and Biotechnology
- MAMatthew A. Cooper
The University of Queensland, Division of Chemistry, Research Institute for Bioscience and Biotechnology
Topics & keywords
- Natural product
- Clinical trial
- Product (mathematics)
- Natural (archaeology)
- Drug
- Pharmacology
- Medicine
- Chemistry