Principles and Current Strategies for Targeting Autophagy for Cancer Treatment
Rutgers, The State University of New Jersey · National Institutes of Health · +7 more institutions
Abstract
Autophagy is an evolutionarily conserved, intracellular self-defense mechanism in which organelles and proteins are sequestered into autophagic vesicles that are subsequently degraded through fusion with lysosomes. Cells, thereby, prevent the toxic accumulation of damaged or unnecessary components, but also recycle these components to sustain metabolic homoeostasis. Heightened autophagy is a mechanism of resistance for cancer cells faced with metabolic and therapeutic stress, revealing opportunities for exploitation as a therapeutic target in cancer. We summarize recent developments in the field of autophagy and cancer and build upon the results presented at the Cancer Therapy Evaluation Program (CTEP) Early…
Citation impact
- FWCI
- 60.09
- Percentile
- 100%
- References
- 113
Authors
9- RKRavi K. AmaravadiCorresponding
Rutgers, The State University of New Jersey, National Institutes of Health, Johnson University, UPMC Hillman Cancer Center, National Cancer Institute, Cancer Institute of Florida, Rutgers Cancer Institute, Indiana University School of Medicine, Indiana University – Purdue University Indianapolis
- JLJennifer Lippincott‐Schwartz
Rutgers, The State University of New Jersey, National Institutes of Health, Johnson University, UPMC Hillman Cancer Center, National Cancer Institute, Cancer Institute of Florida, Rutgers Cancer Institute, Indiana University School of Medicine, Indiana University – Purdue University Indianapolis
- XYXiao-Ming Yin
Rutgers, The State University of New Jersey, National Institutes of Health, Johnson University, UPMC Hillman Cancer Center, National Cancer Institute, Cancer Institute of Florida, Rutgers Cancer Institute, Indiana University School of Medicine, Indiana University – Purdue University Indianapolis
- WAWilliam A. Weiss
Rutgers, The State University of New Jersey, National Institutes of Health, Johnson University, UPMC Hillman Cancer Center, National Cancer Institute, Cancer Institute of Florida, Rutgers Cancer Institute, Indiana University School of Medicine, Indiana University – Purdue University Indianapolis
- NTNaoko Takebe
Rutgers, The State University of New Jersey, National Institutes of Health, Johnson University, UPMC Hillman Cancer Center, National Cancer Institute, Cancer Institute of Florida, Rutgers Cancer Institute, Indiana University School of Medicine, Indiana University – Purdue University Indianapolis
Topics & keywords
- Autophagy
- Cancer
- Cancer cell
- Mechanism (biology)
- Biology
- Cancer research
- Medicine
- Cell biology
- Good health and well-being