Human Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer
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Abstract
Recent reports have suggested the involvement of gut microbiota in the progression of colorectal cancer (CRC). We utilized pyrosequencing based analysis of 16S rRNA genes to determine the overall structure of microbiota in patients with colorectal cancer and healthy controls; we investigated microbiota of the intestinal lumen, the cancerous tissue and matched noncancerous normal tissue. Moreover, we investigated the mucosa-adherent microbial composition using rectal swab samples because the structure of the tissue-adherent bacterial community is potentially altered following bowel cleansing. Our findings indicated that the microbial structure of the intestinal lumen and cancerous tissue differed significantly.…
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1,064
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- 15.18
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- 100%
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5Topics & keywords
Topics
Keywords
- Firmicutes
- Gut flora
- Biology
- Fusobacterium
- Bifidobacterium
- Roseburia
- Microbiology
- Bacteroidetes
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