Transient expression of doublecortin during adult neurogenesis
University of Regensburg · Volkswagen Foundation · +2 more institutions
Abstract
During development of the central nervous system, expression of the microtubule binding protein doublecortin (DCX) is associated with migration of neuroblasts. In addition to this developmental role, expression of DCX remains high within certain areas of the adult mammalian brain. These areas, mainly the dentate gyrus and the lateral ventricle wall in conjunction with the rostral migratory stream and olfactory bulb, retain the capacity to generate new neurons into adulthood. Adult neurogenesis is typically detected by incorporation of bromodeoxyuridine (BrdU) into dividing cells and colabeling of BrdU-positive cells with markers for mature neurons. To elucidate whether DCX could act as an alternative indicator…
Citation impact
- FWCI
- 16.53
- Percentile
- 100%
- References
- 47
Authors
6- JPJason P. Brown
University of Regensburg
- SCSébastien Couillard‐Després
Volkswagen Foundation, Cooper Clinic, University of Regensburg
- CMChristiana M. Cooper‐Kuhn
Cooper Clinic, University of Regensburg
- JWJürgen Winkler
University of California San Diego, University of Regensburg
- LALudwig Aigner
Volkswagen Foundation, University of Regensburg
Topics & keywords
- Doublecortin
- Neurogenesis
- Neuroblast
- Dentate gyrus
- Biology
- Rostral migratory stream
- Neuroscience
- Bromodeoxyuridine