Changes in Body Composition during Androgen Deprivation Therapy for Prostate Cancer
Massachusetts General Hospital · Dana-Farber Cancer Institute
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Abstract
The aim of this study was to determine the effects of initial treatment with a GnRH agonist on body composition in asymptomatic men with nonmetastatic prostate cancer. Forty men with locally advanced, node-positive or biochemically recurrent prostate cancer, no radiographic evidence of metastases, and no prior androgen deprivation therapy were treated with leuprolide 3-month depot 22.5 mg im every 12 wk for 48 wk. The main outcome measures were percentage changes in weight, percentage fat body mass, percentage lean body mass, fat distribution, and muscle size after 48 wk. Thirty-two subjects were evaluable. Serum T concentrations decreased by 96.3% plus or minus 0.4% (P
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7Topics & keywords
Topics
Keywords
- Lean body mass
- Medicine
- Prostate cancer
- Androgen deprivation therapy
- Internal medicine
- Endocrinology
- Prostate
- Asymptomatic
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