Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells
Capital Medical University · Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
Abstract
Mesenchymal stem cells (MSCs), in addition to their multilineage differentiation, have a direct immunosuppressive effect on T-cell proliferation in vitro. However, it is unclear whether they also modulate the immune system by acting on the very first step. In this investigation, we addressed the effects of human MSCs on the differentiation, maturation, and function of dendritic cells (DCs) derived from CD14+ monocytes in vitro. Upon induction with granulocyte-macrophage colony-stimulating factor (GM-CSF) plus interleukin-4 (IL-4), MSC coculture could strongly inhibit the initial differentiation of monocytes to DCs, but this effect is reversible. In particular, such suppression could be recapitulated with no…
Citation impact
- FWCI
- 15.22
- Percentile
- 100%
- References
- 44
Authors
7Topics & keywords
- Mesenchymal stem cell
- CD80
- Cell biology
- CD14
- CD86
- Monocyte
- Dendritic cell
- Cellular differentiation