Brain Tissue Responses to Neural Implants Impact Signal Sensitivity and Intervention Strategies
University of Pittsburgh · Center for the Neural Basis of Cognition · +1 more institution
Abstract
Implantable biosensors are valuable scientific tools for basic neuroscience research and clinical applications. Neurotechnologies provide direct readouts of neurological signal and neurochemical processes. These tools are generally most valuable when performance capacities extend over months and years to facilitate the study of memory, plasticity, and behavior or to monitor patients' conditions. These needs have generated a variety of device designs from microelectrodes for fast scan cyclic voltammetry (FSCV) and electrophysiology to microdialysis probes for sampling and detecting various neurochemicals. Regardless of the technology used, the breaching of the blood-brain barrier (BBB) to insert devices…
Citation impact
- FWCI
- 9.07
- Percentile
- 100%
- References
- 232
Authors
5- TDTakashi D.Y. KozaiCorresponding
University of Pittsburgh, Center for the Neural Basis of Cognition, McGowan Institute for Regenerative Medicine
- AJAndrea Jaquins‐Gerstl
University of Pittsburgh, Center for the Neural Basis of Cognition, McGowan Institute for Regenerative Medicine
- ALAlberto L. Vazquez
University of Pittsburgh, Center for the Neural Basis of Cognition, McGowan Institute for Regenerative Medicine
- ACAdrian C. Michael
University of Pittsburgh, Center for the Neural Basis of Cognition, McGowan Institute for Regenerative Medicine
- XTXinyan Tracy Cui
University of Pittsburgh, Center for the Neural Basis of Cognition, McGowan Institute for Regenerative Medicine
Topics & keywords
- Neuroscience
- Neurochemical
- Brain implant
- Electrophysiology
- Microdialysis
- Medicine
- Microelectrode
- SIGNAL (programming language)