Gastric Cancer Originating from Bone Marrow-Derived Cells
United States Department of Veterans Affairs · University of Massachusetts Chan Medical School · +4 more institutions
Abstract
Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow-derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have…
Citation impact
- FWCI
- 42.58
- Percentile
- 100%
- References
- 18
Authors
10- JHJeanMarie HoughtonCorresponding
United States Department of Veterans Affairs, University of Massachusetts Chan Medical School, Vanderbilt University, University of Tokyo Hospital, Massachusetts Institute of Technology, The University of Tokyo
- CSCalin Stoicov
United States Department of Veterans Affairs, University of Massachusetts Chan Medical School, Vanderbilt University, University of Tokyo Hospital, Massachusetts Institute of Technology, The University of Tokyo
- SNSachiyo Nomura
United States Department of Veterans Affairs, University of Massachusetts Chan Medical School, Vanderbilt University, University of Tokyo Hospital, Massachusetts Institute of Technology, The University of Tokyo
- ABArlin B. Rogers
United States Department of Veterans Affairs, University of Massachusetts Chan Medical School, Vanderbilt University, University of Tokyo Hospital, Massachusetts Institute of Technology, The University of Tokyo
- JEJane E. Carlson
United States Department of Veterans Affairs, University of Massachusetts Chan Medical School, Vanderbilt University, University of Tokyo Hospital, Massachusetts Institute of Technology, The University of Tokyo
Topics & keywords
- Cancer
- Bone marrow
- Pathology
- Dysplasia
- Malignancy
- Inflammation
- Metaplasia
- Cancer research
- Good health and well-being