Mitochondrial dynamics and mitochondrial quality control

Mitochondria are cellular energy powerhouses that play important roles in maintaining cell survival, cell death and cellular metabolic homeostasis. Timely removal of damaged mitochondria via autophagy (mitophagy) is thus critical for cellular homeostasis and function. Mitochondria are reticular organelles that have high plasticity for their dynamic structures and constantly undergo fission and fusion as well as movement through the cytoskeleton. In this review, we discuss the most recent progress on the molecular mechanisms and roles of mitochondrial fission/fusion and mitochondrial motility in mitophagy. We also discuss multiple pathways leading to the quality control of mitochondria in addition to the…

• NI
  National Institutes of Health

  Award: P20 GM103418
• NI
  National Institute on Alcohol Abuse and Alcoholism

  Awards: R01 DK102142, R01 AA020518
• NI
  National Institute of General Medical Sciences

  Awards: 8P20 GM103549, T32 ES007079)
• NC
  National Center for Research Resources

  Award: 5P20RR021940