Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence
Université Toulouse III - Paul Sabatier · Université Fédérale de Toulouse Midi-Pyrénées · +9 more institutions
Abstract
Tuberculosis (TB) is characterized by a tight interplay between Mycobacterium tuberculosis and host cells within granulomas. These cellular aggregates restrict bacterial spreading, but do not kill all the bacilli, which can persist for years. In-depth investigation of M. tuberculosis interactions with granuloma-specific cell populations are needed to gain insight into mycobacterial persistence, and to better understand the physiopathology of the disease. We have analyzed the formation of foamy macrophages (FMs), a granuloma-specific cell population characterized by its high lipid content, and studied their interaction with the tubercle bacillus. Within our in vitro human granuloma model, M. tuberculosis long…
Citation impact
- FWCI
- 11.48
- Percentile
- 100%
- References
- 47
Authors
12- PPPascale Peyron
Université Toulouse III - Paul Sabatier, Université Fédérale de Toulouse Midi-Pyrénées, Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique
- JVJulien Vaubourgeix
Université Fédérale de Toulouse Midi-Pyrénées, Université Toulouse III - Paul Sabatier, Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale
- YPYannick Poquet
Université Fédérale de Toulouse Midi-Pyrénées, Institut de Pharmacologie et de Biologie Structurale, Université Toulouse III - Paul Sabatier, Centre National de la Recherche Scientifique
- FLFlorence Levillain
Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Université Fédérale de Toulouse Midi-Pyrénées, Université Toulouse III - Paul Sabatier
- CBCatherine Botanch
Institut de Pharmacologie et de Biologie Structurale, Université Fédérale de Toulouse Midi-Pyrénées, Centre National de la Recherche Scientifique, Université Toulouse III - Paul Sabatier
Topics & keywords
- Mycobacterium tuberculosis
- Tuberculosis
- Microbiology
- Biology
- Mycobacterium
- Population
- Granuloma
- Mycolic acid
- Good health and well-being