Endothelial cell diversity revealed by global expression profiling
Howard Hughes Medical Institute · University of Oslo · +2 more institutions
Abstract
The vascular system is locally specialized to accommodate widely varying blood flow and pressure and the distinct needs of individual tissues. The endothelial cells (ECs) that line the lumens of blood and lymphatic vessels play an integral role in the regional specialization of vascular structure and physiology. However, our understanding of EC diversity is limited. To explore EC specialization on a global scale, we used DNA microarrays to determine the expression profile of 53 cultured ECs. We found that ECs from different blood vessels and microvascular ECs from different tissues have distinct and characteristic gene expression profiles. Pervasive differences in gene expression patterns distinguish the ECs…
Citation impact
- FWCI
- 17.18
- Percentile
- 100%
- References
- 34
Authors
11- JCJen‐Tsan Chi
Howard Hughes Medical Institute, University of Oslo, Stanford University
- HYHoward Y. Chang
Howard Hughes Medical Institute, University of Oslo, University Dermatology, Stanford University
- GHGuttorm Haraldsen
Howard Hughes Medical Institute, University of Oslo, Stanford University
- FLFrode L. Jahnsen
Howard Hughes Medical Institute, University of Oslo, Stanford University
- OGOlga G. Troyanskaya
Howard Hughes Medical Institute, University of Oslo, Stanford University
Topics & keywords
- Biology
- Cell biology
- Gene expression profiling
- Gene expression
- Regulation of gene expression
- Gene
- Cell type
- Endothelial stem cell