Strategy for Investigating Interactions Between Measured Genes and Measured Environments

The purpose of this article is to promote research that tests hypotheses of measured gene-environment interaction (GxE). A GxE occurs when the effect of exposure to an environmental pathogen on health is conditional on a person's genotype (or conversely, when environmental experience moderates genes' effects on health). Gene-environment interactions were thought to be rare in psychiatry, but empirical findings of measured GxEs are now emerging. However, the current high level of curiosity about GxE is accompanied by uncertainty about the feasibility of GxE research and by pragmatic questions about how to carry out good GxE studies. First, we summarize emerging evidence about GxE in psychiatric disorders.…