Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network
Beth Israel Deaconess Medical Center · Howard Hughes Medical Institute · +4 more institutions
Abstract
Forming distinct representations of multiple contexts, places, and episodes is a crucial function of the hippocampus. The dentate gyrus subregion has been suggested to fulfill this role. We have tested this hypothesis by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-d-aspartate (NMDA) receptor NR1, specifically in dentate gyrus granule cells. The mutant mice performed normally in contextual fear conditioning, but were impaired in the ability to distinguish two similar contexts. A significant reduction in the context-specific modulation of firing rate was observed in the CA3 pyramidal cells when the mutant mice were transferred from one context to…
Citation impact
- FWCI
- 17.43
- Percentile
- 100%
- References
- 37
Authors
10- TJThomas J. McHughCorresponding
Beth Israel Deaconess Medical Center, Howard Hughes Medical Institute, McGovern Institute for Brain Research, University of California, Los Angeles, Massachusetts Institute of Technology
- MWMatthew W. JonesCorresponding
Beth Israel Deaconess Medical Center, Howard Hughes Medical Institute, McGovern Institute for Brain Research, University of California, Los Angeles, Massachusetts Institute of Technology
- JJJennifer J. QuinnCorresponding
Beth Israel Deaconess Medical Center, Howard Hughes Medical Institute, McGovern Institute for Brain Research, University of California, Los Angeles, Yale University, Massachusetts Institute of Technology
- NBNina BalthasarCorresponding
Beth Israel Deaconess Medical Center, Howard Hughes Medical Institute, McGovern Institute for Brain Research, University of California, Los Angeles, Massachusetts Institute of Technology
- RCRoberto CoppariCorresponding
Beth Israel Deaconess Medical Center, Howard Hughes Medical Institute, McGovern Institute for Brain Research, University of California, Los Angeles, Massachusetts Institute of Technology
Topics & keywords
- Dentate gyrus
- Neuroscience
- Hippocampal formation
- NMDA receptor
- Receptor
- Hippocampus
- Biology
- Granule cell