Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by Taq IA A1 Allele
Oregon Research Institute · University of Oregon · +3 more institutions
Abstract
The dorsal striatum plays a role in consummatory food reward, and striatal dopamine receptors are reduced in obese individuals, relative to lean individuals, which suggests that the striatum and dopaminergic signaling in the striatum may contribute to the development of obesity. Thus, we tested whether striatal activation in response to food intake is related to current and future increases in body mass and whether these relations are moderated by the presence of the A1 allele of the TaqIA restriction fragment length polymorphism, which is associated with dopamine D2 receptor (DRD2) gene binding in the striatum and compromised striatal dopamine signaling. Cross-sectional and prospective data from two…
Citation impact
- FWCI
- 21.34
- Percentile
- 100%
- References
- 33
Authors
4- ESEric SticeCorresponding
Oregon Research Institute, University of Oregon, Yale University, John B. Pierce Laboratory, The University of Texas at Austin
- STSonja T.P. Spoor
Oregon Research Institute, University of Oregon, Yale University, John B. Pierce Laboratory, The University of Texas at Austin
- CBCara Bohon
Oregon Research Institute, University of Oregon, Yale University, John B. Pierce Laboratory, The University of Texas at Austin
- DMDana M. Small
Oregon Research Institute, University of Oregon, Yale University, John B. Pierce Laboratory, The University of Texas at Austin
Topics & keywords
- Striatum
- Ventral striatum
- Dopamine
- Dopaminergic
- Dopamine receptor D2
- Internal medicine
- Endocrinology
- Biology
- Zero hunger