reviewCirculation ResearchFeb 2, 2012BRONZE OA

Circulating MicroRNAs

EEEsther E. CreemersAJAnke J. TijsenYMYigal M. Pinto

Amsterdam UMC Location University of Amsterdam · Amsterdam University Medical Centers

PubMed
Indexed incrossrefpubmed

Abstract

In the past few years, the crucial role of different micro-RNAs (miRNAs) in the cardiovascular system has been widely recognized. Recently, it was discovered that extracellular miRNAs circulate in the bloodstream and that such circulating miRNAs are remarkably stable. This has raised the possibility that miRNAs may be probed in the circulation and can serve as novel diagnostic markers. Although the precise cellular release mechanisms of miRNAs remain largely unknown, the first studies revealed that these circulating miRNAs may be delivered to recipient cells, where they can regulate translation of target genes. In this review, we will discuss the nature of the stability of miRNAs that circulate in the…

Citation impact

1,005
total citations
FWCI
33.50
Percentile
100%
References
71
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • microRNA
  • Biology
  • Function (biology)
  • Microvesicles
  • Translation (biology)
  • Bioinformatics
  • Myocardial infarction
  • Computational biology
UN Sustainable Development Goals
  • Good health and well-being
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