Evidence for a cross-talk between human neutrophils and Th17 cells

Interleukin-17A (IL-17A) and IL-17F are 2 of several cytokines produced by T helper 17 cells (Th17), which are able to indirectly induce the recruitment of neutrophils. Recently, human Th17 cells have been phenotypically characterized and shown to express discrete chemokine receptors, including CCR2 and CCR6. Herein, we show that highly purified neutrophils cultured with interferon-gamma plus lipopolysaccharide produce the CCL2 and CCL20 chemokines, the known ligands of CCR2 and CCR6, respectively. Accordingly, supernatants from activated neutrophils induced chemotaxis of Th17 cells, which was greatly suppressed by anti-CCL20 and anti-CCL2 antibodies. We also discovered that activated Th17 cells could directly…

• AI
  Associazione Italiana per la Ricerca sul Cancro
• FC
  Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona
• UD
  Università degli Studi di Verona
• CI
  Canadian Institutes of Health Research