articleHepatologyJul 25, 2007BRONZE OA

A lipidomic analysis of nonalcoholic fatty liver disease

PPPuneet PuriRBRebecca BaillieMMMichelle M. WiestFMFaridoddin MirshahiJCJayanta Choudhury

Virginia Commonwealth University Medical Center

PubMed
Indexed incrossrefpubmed

Abstract

UNLABELLED: The spectrum of nonalcoholic fatty liver disease (NAFLD) includes a nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). The specific types and amounts of lipids that accumulate in NAFLD are not fully defined. The free fatty acid (FFA), diacylglycerol (DAG), triacylglycerol (TAG), free cholesterol (FC), cholesterol ester, and phospholipid contents in normal livers were quantified and compared to those of NAFL and NASH, and the distribution of fatty acids within these classes was compared across these groups. Hepatic lipids were quantified by capillary gas chromatography. The mean (nmol/g of tissue) DAG (normal/NAFL/NASH: 1922 versus 4947 versus 3304) and TAG (13,609 versus…

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Topics & keywords

Topics
Keywords
  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis
  • Fatty liver
  • Medicine
  • Internal medicine
  • Gastroenterology
  • Disease
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